Sometimes in individuals with rheumatoid arthritis, subcutaneous nodules can develop. These tend to be firm and are not tender to touch, and develop on around a quarter of rheumatoid arthritis patients. They can vary in size and usually develop at pressure points such as the back of the forearm, the elbow, metacarpophalangeal joint and pressure points on the knees and feet. The nodules mainly occur in chronic cases of rheumatoid arthritis, and can be associated with joint deformity and extra- articular menifestations of the condition, where organs such as the lungs and eyes are affected.

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